BAY 59-7939
Rivaroxaban
CAS: 366789-02-8
Molecular Formula: C19H18ClN3O5S
BAY 59-7939 - Names and Identifiers
| Name | Rivaroxaban |
| Synonyms | rivaroxban BAY 59-7939 Rivaroxaban (S)-Rivaroxaban Rivaroxaban Isomer Rivaroxaban intermediates (S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carbox 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamide 5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide RIVAROXABAN STAGE-IV [5-CHLORO-N-({5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-1,3-OXAZOLIDIN-5-YL}-METHYL)-2(AS PER INV |
| CAS | 366789-02-8 |
| EINECS | 685-132-2 |
| InChI | InChI=1/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 |
BAY 59-7939 - Physico-chemical Properties
| Molecular Formula | C19H18ClN3O5S |
| Molar Mass | 435.88 |
| Density | 1.460±0.06 g/cm3(Predicted) |
| Melting Point | 228-229°C |
| Boling Point | 732.6±60.0 °C(Predicted) |
| Flash Point | 396.868°C |
| Solubility | DMSO 87 mg/mL Ethanol <1 mg/mL |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 13.36±0.46(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.633 |
BAY 59-7939 - Reference
| Reference Show more | 1. Yuan Dongdong, Wang Yalei, Zhang Hanjuan, Wang Gao Biao, Guo Liping, Ke Yu. Determination of rivaroxaban plasma concentration in patients with atrial fibrillation by LC-MS/MS [J]. Journal of Pharmaceutical Analysis, 2020,40(08):1399-1404. 2. [IF = 3.727] Zhao Tingting et al."Identifying the Dominant Contribution of Human Cytochrome P450 2J2 to the Metabolism of Rivaroxaban, an Oral anticopuallant." Cardiovasular Drugs And Therapy. 2021 Jan 07 |
BAY 59-7939 - Introduction
Rivaroxaban (Rivaroxaban) is a novel oral anticoagulant and a selective FXa inhibitor acting on the active site of factor Xa (FXa). It inhibits the intrinsic and extrinsic coagulation pathways in a dose-dependent manner by inhibiting FXa, thereby inhibiting thrombosis. It can be used in adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis. It can also be used in adult patients with non-valvular atrial fibrillation with a history of stroke or transient ischemic attack to reduce the risk of stroke and systemic embolism.
The indications for rivaroxaban tablets include: 1. It is used in adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis (VTE). 2. It is used to treat adult venous thrombosis (DVT) and reduce the risk of DVT recurrence and pulmonary embolism (PE) after acute DVT. 3. Use in adult patients with non-valvular atrial fibrillation with one or more risk factors (eg, congestive heart failure, hypertension, age ≥ 75 years, diabetes, history of stroke or transient ischemic attack) to reduce the risk of stroke and systemic embolism.
In patients with severe renal impairment (creatinine clearance <30 mL/min), blood concentrations of rivaroxaban may be significantly elevated, leading to an increased risk of bleeding. Rivaroxaban is not recommended for patients with creatinine clearance <15 mL/min. Rivaroxaban should be used with caution in patients with a creatinine clearance of 15-29 mL/min. Rivaroxaban should be used with caution in patients with moderate renal impairment (creatinine clearance 30-49 mL/min) when concomitant use of other drugs that increase the plasma concentration of rivaroxaban.
Last Update：2023-08-16 23:22:23
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